您需要检查 DataGridViewCell 的 Value 属性是否为null或所以你可以这样做：

You need to check if the Value property of the DataGridViewCell is null or not.So you can do something like:

Public Function IsDataGridViewEmpty(ByRef dataGridView As DataGridView) As Boolean
    Dim isEmpty As Boolean
    isEmpty = True
    For Each row As DataGridViewRow In dataGridView.Rows
        For Each cell As DataGridViewCell In row.Cells
            If Not String.IsNullOrEmpty(cell.Value) Then
                ' Check if the string only consists of spaces
                If Not String.IsNullOrEmpty(Trim(cell.Value.ToString())) Then
                    isEmpty = False
                    Exit For
                End If
            End If
        Next
    Next
    Return isEmpty
End Function

或，可以查看..

http://social.msdn.microsoft.com/Forums/en-US/0fa5f291-35d2- 4ecf-afb1-9f52ab959109 / data-grid-in-vbnet [ ^ ]

Or, can view..
http://social.msdn.microsoft.com/Forums/en-US/0fa5f291-35d2-4ecf-afb1-9f52ab959109/data-grid-in-vbnet[^]

然后你需要在搜索按钮上写下这段代码搜索过程

then you need to write this code on your search button after the search process

If DataGridView1.RowCount > 0 Then
    btnSave.Enabled = True
Else
    btnSave.Enabled = False
End If